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Oxygen consumption during surface-induced deep hypothermia under halothane anesthesia

T Ishitoya, S Sato, G DiBenedetto

    The Annals of Thoracic Surgery
    |January 1, 1977
    PubMed
    Summary
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    Halothane anesthesia during deep hypothermia and circulatory arrest did not alter overall oxygen consumption. However, significant differences in cardiac output and oxygen levels during rewarming were observed, potentially explaining postoperative issues.

    Area of Science:

    • Anesthesiology
    • Cardiovascular Physiology
    • Hypothermia Research

    Background:

    • Deep hypothermia with circulatory arrest (HCA) is used in complex surgeries.
    • Postoperative neurological deficits are a concern after HCA.
    • Halothane anesthesia's impact on physiological parameters during HCA requires further investigation.

    Purpose of the Study:

    • To compare oxygen consumption and physiological responses in dogs under halothane versus ether anesthesia during deep hypothermia and 30 minutes of circulatory arrest.
    • To investigate potential causes for postoperative motor disturbances observed with halothane anesthesia.

    Main Methods:

    • Ten dogs underwent surface-induced deep hypothermia and 30 minutes of circulatory arrest.
    • Anesthesia was maintained with halothane and 100% oxygen.

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  • Physiological parameters, including oxygen consumption, cardiac output, and arterial blood gases, were monitored.
  • Results were compared to historical data using ether anesthesia.

    • Main Results:

    • Oxygen consumption was identical between the halothane and ether anesthesia groups.
    • The halothane group exhibited significantly lower cardiac output during rewarming.
    • Lower partial pressure of oxygen (PaO2) and a larger arteriovenous oxygen difference were noted during rewarming in the halothane group.

    Conclusions:

    • Despite similar oxygen consumption, halothane anesthesia induced distinct cardiovascular and respiratory changes during rewarming after deep hypothermia and circulatory arrest.
    • These physiological alterations may contribute to postoperative motor disturbances, though the exact mechanism remains unclear.
    • Further research is needed to fully understand the implications of halothane anesthesia in HCA protocols.