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Typical, modified, and atypical measles

R C Welliver, J D Cherry, A E Holtzman

Archives of Internal Medicine

|January 1, 1977

Summary

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Measles outbreaks can occur despite vaccination. This study examined cases of atypical measles, primary measles, and vaccine failures, highlighting the need for internists to remain vigilant.

Area of Science:

Epidemiology
Infectious Diseases
Immunology

Background:

Measles outbreaks pose a public health concern.
Vaccine efficacy and waning immunity are critical factors in disease transmission.

Purpose of the Study:

To investigate the characteristics of a measles outbreak in 1975.
To analyze different measles presentations and vaccine failure mechanisms.

Main Methods:

Case study analysis of a small measles outbreak.
Clinical and serologic evaluation of affected individuals.

Main Results:

One case of atypical measles in an individual previously vaccinated with killed measles vaccine.
One case of typical primary measles.

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Two cases of live measles vaccine failure, one suggesting primary vaccine failure and the other a possible secondary immunologic response.

Conclusions:

Measles remains a concern for internists, even with vaccination.
Understanding vaccine failure is crucial for disease control and prevention strategies.