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Related Experiment Videos

MR imaging of the developing human brain. Part 2. Postnatal development

M C Ballesteros1, P E Hansen, K Soila

  • 1Department of Diagnostic Radiology, Mount Sinai Medical Center, Miami Beach, FL 33140.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|May 1, 1993
PubMed
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This study details normal brain maturation in infants using magnetic resonance (MR) imaging. It maps changes in white matter myelination and corpus callosum development, crucial for diagnosing infant brain conditions.

Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Developmental Neuroscience

Background:

  • Infant brain development involves complex myelination processes.
  • Understanding normal maturation is key for identifying developmental abnormalities.

Purpose of the Study:

  • To evaluate normal brain maturation patterns in neonates and infants up to 24 months.
  • To document sequential changes in myelination and corpus callosum development using MR imaging.

Main Methods:

  • Retrospective analysis of in vivo magnetic resonance (MR) brain images.
  • Observation of signal intensity changes in gray matter, white matter, and corpus callosum over time.

Main Results:

  • Neonatal white matter signal intensity differs from adults on T1- and T2-weighted MR images.

Related Experiment Videos

  • Progressive myelination alters white matter signal intensity with age.
  • Corpus callosum matures to adult appearance by 8 months.

    • Conclusions:

    • MR imaging reveals distinct temporal sequences of myelination and corpus callosum development.
    • Familiarity with these normal maturation patterns aids in diagnosing pediatric white matter pathologies.