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[Stress-induced immune changes, and brain-immune interaction]

S Nagata1

  • 1Department of Mental Health, University of Occupational and Environmental Health, Kitakyusyu, Japan.

Journal of UOEH
|June 1, 1993
PubMed
Summary

Psychosocial stress significantly impacts immune function and increases infection susceptibility. This review details the bidirectional communication between the brain and immune system, highlighting stress-induced immune changes.

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Area of Science:

  • Neuroscience
  • Immunology
  • Psychoneuroimmunology

Context:

  • Psychosocial stress is a known modulator of the immune system.
  • Recent advances elucidate mechanisms of stress-induced immune alterations and brain-immune interactions.
  • Studies link stressful events to increased susceptibility to infections and neoplastic risks.

Purpose:

  • To review and discuss stress-induced immune changes.
  • To explore the intricate brain-immune interactions.
  • To synthesize current literature on the bidirectional communication between the central nervous system and the immune system.

Summary:

  • Psychosocial stress affects immune cells, leading to reduced phagocytosis, lymphocyte response, and natural killer cell activity.
  • Bidirectional communication pathways involve cytokines, neuropeptides, the autonomic nervous system, and the hypothalamic-pituitary-adrenal axis.

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  • Immune and allergic responses can be classically conditioned, demonstrating a complex interplay between psychological states and physiological responses.

    • Impact:

    • Provides a comprehensive overview of psychoneuroimmunology.
    • Highlights the mechanisms underlying stress's influence on health.
    • Informs future research on stress management and immune system modulation.