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Solitary thyroid nodules

R D Liechty, P T Stoffel, D E Zimmerman

    Archives of Surgery (Chicago, Ill. : 1960)
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    In a study of solitary thyroid nodules, 17.9% were malignant, a threefold increase compared to earlier research. Researchers recommend surgical excision for all persistent thyroid nodules.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Surgical Pathology

    Background:

    • Solitary thyroid nodules are common, but distinguishing benign from malignant ones is crucial for patient management.
    • Previous studies have reported varying rates of malignancy in solitary thyroid nodules.
    • Strict patient selection criteria were employed to focus on nodules with a lower pre-existing probability of cancer.

    Purpose of the Study:

    • To determine the prevalence of histologic malignancy in solitary thyroid nodules after applying strict exclusion criteria.
    • To compare current malignancy rates with historical data and contemporary findings from cancer centers.

    Main Methods:

    • A cohort of 67 patients with solitary thyroid nodules was evaluated.
    • Strict criteria, including absence of radiation history to the neck, were used to select patients.

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  • Histologic examination was performed on excised nodules.

    • Main Results:

    • Twelve out of 67 patients (17.9%) were diagnosed with histologic malignancy.
    • This malignancy rate is approximately threefold higher than reported in a previous study by the same author.
    • Thyroid suppression therapy resulted in definite but incomplete shrinking of three nodules, one of which was malignant.

    Conclusions:

    • The observed malignancy rate in solitary thyroid nodules, even with strict criteria, remains significant.
    • The potential increase in malignancy rates may be due to improved patient screening or actual incidence changes.
    • Surgical excision is advised for all persistent thyroid nodules to ensure accurate diagnosis and treatment.