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Updated: Aug 19, 2026
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
[Prognosis for infants with birth weights less than 1,501 g treated in a central hospital]
J Thaarup1, O Kierkegaard, M Dirdal
1Paediatrisk afdeling, Herning Centralsygehus.
Insights
This study on very low birth weight infants found higher mortality in the 1251-1500 gram group, primarily due to respiratory distress syndrome. Survivors had fewer chronic lung issues and neurological sequelae compared to other centers.
Area of Science:
- Neonatalogy
- Pediatric Medicine
- Public Health
Context:
- Retrospective review of very low birth weight (<1501 grams) infants born in Ringkoebing county between 1981-1990.
- Focus on mortality, morbidity, and major sequelae without neonatal ventilator treatment.
Purpose:
- To assess the outcomes of very low birth weight infants in a specific region and time period.
- To compare these outcomes with contemporary national and international data.
Summary:
- Neonatal survival rate was 63% (143/227 infants).
- Excess mortality was observed in infants weighing 1251-1500 grams, mainly due to respiratory distress syndrome (62% of neonatal deaths).
- Among survivors, 28% required prolonged oxygen, and 6% had major neurological sequelae; however, chronic lung disease and neurological sequelae incidence may be lower than in other centers.
Impact:
- Provides regional data on very low birth weight infant outcomes.
- Suggests potential for improved management strategies to reduce mortality and long-term complications.
- Highlights the impact of respiratory distress syndrome on neonatal mortality in this population.
Abstract:
The mortality, morbidity and major sequelae for children with very low birth weight (< 1501 grams) born in the county of Ringkoebing, from 1981 to 1990 were reviewed retrospectively. Ventilator treatment was not used in the neonatal period. Neonatal survival was 63% (143 of 227 infants); the excess mortality compared with contemporary investigations was found in the group 1251-1500 grams and was mainly due to respiratory distress syndrome, which, in the whole population, was an important factor in 62% of neonatal deaths. Among 11 with bronchopulmonary dysplasia and six with Wilson-Mikity syndrome, only three died from Wilson-Mikity syndrome and three had minor pulmonary symptoms, but were healthy at one year of age. Twenty eight per cent of neonatal survivors received supplementary oxygen for more than 28 days. Six per cent of neonatal survivors had major neurological sequelae; i.e. higher neonatal mortality but probably lower incidence of chronic lung disease and major neurological sequelae than reported from contemporary Danish and foreign centres.
