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Serum myocardial enzymes after +Gz acceleration
Aviation, Space, and Environmental Medicine
|January 1, 1977
Summary
High +Gz acceleration in humans did not cause significant myocardial damage. A minor increase in creatine phosphokinase (CPK) suggests enhanced skeletal muscle cell permeability from exercise.
Area of Science:
- Aerospace Medicine
- Cardiovascular Physiology
- Biochemistry
Background:
- High +Gz acceleration can impose significant physiological stress.
- Potential for myocardial damage during high +Gz exposure is a concern.
- Enzyme levels in circulation can indicate tissue injury.
Purpose of the Study:
- To investigate myocardial damage during high +Gz acceleration.
- To assess changes in cardiac and muscle enzymes.
- To determine the physiological impact of G-force exposure.
Main Methods:
- Serum samples analyzed for lactate dehydrogenase, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase, and creatine phosphokinase (CPK) and isoenzymes.
- 12 human volunteers exposed to 6, 8, 9, and 10 G acceleration.
- Enzyme levels measured pre-exposure, 6 hours post-exposure, and 24 hours post-exposure.
Main Results:
- No substantial elevations in most measured enzyme activities were observed.
- A statistically significant (p < 0.01) small increase in CPK was detected.
- Multivariate analysis confirmed the CPK increase.
Conclusions:
- High +Gz acceleration does not appear to cause significant myocardial damage.
- The observed CPK increase is likely due to enhanced skeletal muscle cell permeability.
- Muscular exercise associated with G-force exposure may contribute to enzyme level changes.