Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum myocardial enzymes after +Gz acceleration

D R Sellers, J S Kirkland, J A Kennealy

    Aviation, Space, and Environmental Medicine
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Angioplasty with stent placement in peripheral arterial occlusive disease.

    AORN journal·1995
    Same author

    Immunohistochemical localization of substance P and enkephalin in the nucleus tractus solitarii of the rhesus monkey, Macaca mulatta.

    The Journal of comparative neurology·1987
    Same author

    Platelet membrane vesicles reduced microvascular bleeding times in thrombocytopenic rabbits.

    The Journal of laboratory and clinical medicine·1987
    Same author

    Histologic assessment of cathepsin D in osteoarthritic cartilage.

    Clinical and experimental rheumatology·1986
    Same author

    A canalicular system in human articular cartilage: fact or histologic artifact?

    The Journal of rheumatology·1986
    Same author

    In situ saphenous vein bypass for occlusive disease in the lower extremity.

    The Surgical clinics of North America·1986

    High +Gz acceleration in humans did not cause significant myocardial damage. A minor increase in creatine phosphokinase (CPK) suggests enhanced skeletal muscle cell permeability from exercise.

    Area of Science:

    • Aerospace Medicine
    • Cardiovascular Physiology
    • Biochemistry

    Background:

    • High +Gz acceleration can impose significant physiological stress.
    • Potential for myocardial damage during high +Gz exposure is a concern.
    • Enzyme levels in circulation can indicate tissue injury.

    Purpose of the Study:

    • To investigate myocardial damage during high +Gz acceleration.
    • To assess changes in cardiac and muscle enzymes.
    • To determine the physiological impact of G-force exposure.

    Main Methods:

    • Serum samples analyzed for lactate dehydrogenase, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase, and creatine phosphokinase (CPK) and isoenzymes.
    • 12 human volunteers exposed to 6, 8, 9, and 10 G acceleration.

    Related Experiment Videos

  • Enzyme levels measured pre-exposure, 6 hours post-exposure, and 24 hours post-exposure.

    • Main Results:

    • No substantial elevations in most measured enzyme activities were observed.
    • A statistically significant (p < 0.01) small increase in CPK was detected.
    • Multivariate analysis confirmed the CPK increase.

    Conclusions:

    • High +Gz acceleration does not appear to cause significant myocardial damage.
    • The observed CPK increase is likely due to enhanced skeletal muscle cell permeability.
    • Muscular exercise associated with G-force exposure may contribute to enzyme level changes.