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Trousseau's syndrome

N Callander¹, S I Rapaport

¹Department of Medicine, University of California, School of Medicine, San Diego, La Jolla.

The Western Journal of Medicine

|April 1, 1993

Summary

This summary is machine-generated.

Trousseau's syndrome involves blood clots linked to cancer. Unexplained clots treatable with heparin but not warfarin suggest seeking a hidden tumor for diagnosis and management.

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Area of Science:

Oncology
Hematology
Pathology

Background:

Trousseau's syndrome is characterized by venous and arterial thromboses associated with malignancy.
Nonbacterial thrombotic endocarditis can lead to arterial emboli in patients with cancer.

Observation:

Recurrent thromboses, unresponsive to warfarin but sensitive to heparin, are key indicators.
Thrombotic events may precede tumor detection by months or years.

Findings:

Persistent low-grade intravascular coagulation is a hallmark of Trousseau's syndrome.
Successful management requires indefinite heparin therapy, as stopping it can trigger new clots.
Neoplastic cells expressing tissue factor and tumor structure facilitating exposure to blood are crucial for syndrome development.

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Implications:

Physicians should suspect Trousseau's syndrome in cases of unexplained thromboses.
A thorough and ongoing search for occult malignancies is essential in patients with Trousseau's syndrome.
Understanding the molecular basis of Trousseau's syndrome aids in early cancer detection and management.