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Involvement of protein kinase C in various cellular systems transducting ischemia evoked signal
1Department of Neurochemistry, Polish Academy of Sciences, Warsaw.
Acta Neurobiologiae Experimentalis
|January 1, 1993
Abstract:
(1) We favour a hypothesis that the delayed neuronal injury in hippocampus is initiated by the increase of intracellular calcium concentration, activating transiently Ca-dependent protein kinase. (2) The secondary effects of the postischemic, short-lasting PKC translocation/activation could involve: an activation of cAMP signaling pathway; an activation of early response protein like ornitine decarboxylase.