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Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment
F J Zijlstra1, A P van Dijk, R J Ouwendijk
1Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands.
Abstract:
Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of 14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxy-eicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score.
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