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Microbial hydrogenases: primary structure, classification, signatures and phylogeny

L F Wu¹, M A Mandrand

¹Laboratoire de Génétique Moléculaire des Microorganismes, CNRS URA 1486, INSA, Villeurbanne, France.

FEMS Microbiology Reviews

|April 1, 1993

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This study classifies 30 microbial hydrogenases into six classes based on sequence, metal content, and function. Findings reveal distinct evolutionary origins and conserved motifs, aiding in understanding hydrogenase diversity and function.

Area of Science:

Microbiology
Biochemistry
Evolutionary Biology

Background:

Hydrogenases are crucial enzymes catalyzing hydrogen oxidation or production.
Understanding hydrogenase diversity is key to their biotechnological applications.

Purpose of the Study:

To classify sequenced microbial hydrogenases into distinct groups.
To investigate the evolutionary relationships and conserved motifs within hydrogenase classes.

Main Methods:

Sequence homology analysis of 30 microbial hydrogenases.
Phylogenetic tree construction and hierarchical clustering.
Motif analysis of conserved regions within hydrogenase classes.

Main Results:

Thirty hydrogenases were classified into six distinct classes based on sequence, metal content, and function.

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Evolutionary analysis indicated at least three ancestral origins for these hydrogenases.

Conserved motifs were identified in hydrogen activation and electron transfer domains, with variations across classes.

Conclusions:

The classification provides a framework for understanding hydrogenase diversity.
Distinct evolutionary paths and conserved motifs highlight functional specializations.
Further research into conserved motifs can elucidate hydrogen activation mechanisms.