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Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids
T J Hursti1, M Fredrikson, G Steineck
1Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden.
British Journal of Cancer
|July 1, 1993
Abstract:
Lower pre-chemotherapy night time cortisol excretion predicted more severe cisplatin induced nausea and vomiting in 42 ovarian cancer patients receiving ondansetron as a single antiemetic agent. Dexamethasone administration added to the antiemetic effect of ondansetron principally in patients who had low excretion of cortisol.