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Related Experiment Videos

Primary open angle glaucomas in the rhesus monkey

W W Dawson1, D E Brooks, G M Hope

  • 1Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32610.

The British Journal of Ophthalmology
|May 1, 1993
PubMed
Summary
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Ocular hypertension in rhesus monkeys shows a familial pattern, suggesting a genetic link. This finding supports the use of these monkeys as a glaucoma research model.

Area of Science:

  • Primate genetics
  • Ophthalmology
  • Animal models

Background:

  • Rhesus monkeys in a closed colony exhibit familial clustering of elevated intraocular pressure.
  • The colony's genetic purity since 1938 allows for lineage-based studies.

Purpose of the Study:

  • To investigate the familial aggregation of ocular hypertension in rhesus monkeys.
  • To evaluate the potential of these monkeys as a model for glaucoma research.

Main Methods:

  • Analysis of intraocular pressure data across maternal lineages in a genetically closed rhesus monkey colony.
  • Clinical examination and diagnostic assessments of ocular health in selected monkeys, including those with ocular hypertension and low-tension glaucoma.

Main Results:

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  • Elevated intraocular pressure was significantly associated with specific maternal lineages, with some matrilines showing over 40% incidence.
  • Monkeys with ocular hypertension displayed optic nerve abnormalities, including axonal loss and visual field deficits.
  • A case of low-tension glaucoma was identified in a monkey from a low-incidence matriline, highlighting complex disease presentation.

Conclusions:

  • Familial clustering of ocular hypertension in rhesus monkeys provides a strong basis for genetic studies.
  • The observed ocular pathologies and genetic predisposition make these monkeys a valuable model for studying glaucoma.
  • This research underscores the importance of lineage in understanding the inheritance patterns of ocular hypertension and glaucoma.