Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

ABO and platelet transfusion revisited

J M Heal¹, J M Rowe, N Blumberg

¹American Red Cross, Rochester Region, NY 14607.

Annals of Hematology

|June 1, 1993

Summary

ABO-identical platelets significantly improve transfusion outcomes compared to ABO-unmatched platelets. Reclassifying data using conventional ABO compatibility terms obscured these benefits, suggesting a need to redefine transfusion guidelines for better patient results.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Shorter long-term post-transplant life expectancy may be due to prior chemotherapy for the underlying disease: analysis of 3012 patients with acute myeloid leukemia enrolled on 9 consecutive ECOG-ACRIN trials.

Bone marrow transplantation·2024

Same author

Shorter long-term post-transplant life expectancy may be due to prior chemotherapy for the underlying disease: analysis of 3012 patients with acute myeloid leukemia enrolled on 9 consecutive ECOG-ACRIN trials.

Bone marrow transplantation·2024

Same author

Haem is associated with thrombosis in neonates and infants undergoing cardiac surgery for congenital heart disease.

Vox sanguinis·2017

Same author

The evolving role of chemotherapy and hematopoietic cell transplants in Ph-positive acute lymphoblastic leukemia in adults.

Bone marrow transplantation·2017

Same author

Maresin 1 induces a novel pro-resolving phenotype in human platelets.

Journal of thrombosis and haemostasis : JTH·2017

Same author

The NIST Cold Neutron Research Facility.

Journal of research of the National Institute of Standards and Technology·2017

Area of Science:

Hematology
Transfusion Medicine
Immunology

Background:

Historically, ABO compatibility has been considered less critical for platelet transfusions.
Previous studies did not observe significant benefits of ABO-identical platelets, potentially due to terminology.
The conventional grouping of ABO-identical and ABO-compatible platelets may have masked crucial differences.

Purpose of the Study:

To re-evaluate the importance of ABO compatibility in platelet transfusions.
To compare corrected count increment (CCI) data using conventional versus ABO-identical terminology.
To investigate the impact of ABO-incompatible plasma and cumulative transfusion effects on platelet transfusion success.

Main Methods:

Analysis of corrected count increment (CCI) from a previous randomized trial.
Re-analysis of transfusion data using conventional ABO compatibility and incompatibility definitions.
Classification of transfusions based on the number of previous ABO-incompatible or ABO-identical transfusions.

Main Results:

ABO-identical platelets showed a 64% higher mean CCI compared to ABO-unmatched products in the original study.
Re-analysis using conventional ABO compatibility/incompatibility terms eliminated the detected benefits of ABO-identical platelets.
Increasing numbers of ABO-incompatible transfusions were associated with progressively poorer mean increments, indicating cumulative effects.

Conclusions:

The conventional terminology of "ABO compatible" and "ABO incompatible" obscures the significant benefits of ABO-identical platelet transfusions.
Transfusion of ABO-incompatible plasma may lead to immune complex formation, indirectly destroying compatible platelets.
The cumulative effects of ABO-nonidentical transfusions negatively impact subsequent transfusion success, necessitating a re-evaluation of ABO matching importance.

Related Experiment Videos