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Related Experiment Videos

Effect of high concentration perflubron emulsion on platelet function

D J Smith1, T A Lane

  • 1Alliance Pharmaceutical Corporation, San Diego, CA.

Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology
|January 1, 1993
PubMed
Summary

This study shows that perfluorooctylbromide (perflubron) emulsion inhibits platelet activation in pigs and humans. This perfluorocarbon emulsion may reduce side effects associated with perfluorocarbon use.

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Area of Science:

  • Biomedical Engineering
  • Hematology
  • Pharmacology

Background:

  • Perfluorocarbon (PFC) and lipid emulsions can alter platelet function.
  • Platelet activation may mediate PFC-induced side effects.

Purpose of the Study:

  • To investigate the effect of a highly concentrated perfluorooctylbromide (perflubron) emulsion on porcine and human platelet activation and function.

Main Methods:

  • Ex-vivo porcine platelet aggregation was measured before and after perflubron emulsion infusion.
  • In vitro human platelet calcium flux was assessed in the presence of perflubron emulsion.

Main Results:

  • Perflubron emulsion inhibited collagen-, ADP-, and arachidonic acid-stimulated porcine platelet aggregation in a dose-dependent manner.

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  • Perflubron emulsion inhibited A23187- and arachidonic acid-stimulated human platelet calcium flux in vitro.
  • Other emulsions like Fluosol and Intralipid showed similar inhibitory effects.

    • Conclusions:

    • Perflubron emulsion significantly inhibits platelet aggregation and activation.
    • This finding suggests a potential mechanism for mitigating PFC-related side effects.