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Related Experiment Videos

Hemoperfusion and liver disease

G Visco1, R Giannuzzi, M G Paglia

  • 1L. Spallanzani Hospital for Infectious Diseases, Rome, Italy.

Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology
|January 1, 1993
PubMed
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Perfusion techniques show promise for treating liver diseases, including acute hepatic failure and chronic conditions like chronic active hepatitis. These methods also helped manage cryoglobulinemia, a complication of liver disease.

Area of Science:

  • Hepatology
  • Nephrology
  • Immunology

Background:

  • Perfusion techniques have evolved for liver disease treatment over the past two decades.
  • Applications now extend to acute hepatic failure, chronic active hepatitis (CAH), and primary biliary cirrhosis.
  • Cryoglobulinemia, a severe complication of these liver diseases, is also a target for perfusion therapies.

Purpose of the Study:

  • To review existing literature on perfusion techniques for liver diseases and related complications.
  • To present personal data on the application of perfusion in acute liver failure and cryoglobulinemia.
  • To evaluate the efficacy of plasma exchange and hemoperfusion in these conditions.

Main Methods:

  • Literature review of plasma exchange and hemoperfusion in liver disease treatment.

Related Experiment Videos

  • Clinical application in 15 patients with acute viral liver failure.
  • Clinical application in 5 patients with CAH-linked cryoglobulinemia (viral and autoimmune).

    • Main Results:

    • A survival rate of 33% was observed in patients with acute viral liver failure.
    • Good control of disease parameters was achieved in patients with CAH-linked cryoglobulinemia.
    • The study reviewed experiences using both plasma exchange and hemoperfusion.

    Conclusions:

    • Perfusion techniques, including plasma exchange and hemoperfusion, offer therapeutic potential for acute hepatic failure.
    • These methods can effectively manage cryoglobulinemia associated with chronic liver diseases like CAH.
    • Further research and experience are warranted to optimize perfusion strategies in hepatology.