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Related Experiment Videos

Renal function abnormalities after ifosfamide treatment in children

J De Schepper1, S Hachimi-Idrissi, M Verboven

  • 1Department of Pediatrics, Academic Hospital, Free University of Brussels, Belgium.

Acta Paediatrica (Oslo, Norway : 1992)
|April 1, 1993
PubMed
Summary

Ifosfamide chemotherapy can cause significant kidney damage in children, particularly affecting proximal renal tubular function. Younger children receiving higher doses are at increased risk for these adverse renal effects.

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Area of Science:

  • Pediatric Oncology
  • Nephrology
  • Pharmacology

Background:

  • Ifosfamide is a widely used chemotherapeutic agent in pediatric oncology.
  • Potential nephrotoxicity is a known concern with ifosfamide treatment.
  • Long-term renal effects in children require thorough investigation.

Purpose of the Study:

  • To evaluate long-term renal function in children treated with ifosfamide.
  • To identify specific patterns of renal dysfunction and associated risk factors.

Main Methods:

  • Assessed renal glomerular and tubular function via blood and urine analysis in 12 children post-ifosfamide therapy.
  • Utilized isotopic determination for glomerular filtration rate (GFR) assessment.
  • Evaluations were conducted at least four months after treatment cessation.

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Main Results:

  • Three patients exhibited biochemical abnormalities indicative of proximal renal tubular dysfunction.
  • Abnormalities included increased urinary excretion of calcium, glucose, beta-2-microglobulin, and amino acids.
  • One patient showed decreased tubular reabsorption of phosphate, linked to diminished GFR.
  • Younger age at treatment and higher ifosfamide dose per body weight correlated with dysfunction.

Conclusions:

  • Ifosfamide therapy can lead to persistent proximal renal tubular dysfunction in pediatric patients.
  • Younger age and higher cumulative ifosfamide doses are risk factors for ifosfamide-induced nephrotoxicity.
  • Regular monitoring of renal function is crucial for children undergoing ifosfamide chemotherapy.