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Related Experiment Video

Updated: Jul 16, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Perinatal and pediatric nutrition

¹Department of Pathology, University of British Columbia, Vancouver.

Clinics in Laboratory Medicine

|June 1, 1993

Summary

Very low birth weight infants are prone to rapid nutritional deficiencies due to insufficient nutrient accumulation. Breast-fed infants, even full-term ones, require careful monitoring for conditions like zinc deficiency and dehydration.

Area of Science:

Neonatal nutrition
Pediatric deficiencies

Background:

Very low birth weight (VLBW) infants have limited nutrient stores.
Third-trimester nutrient accumulation is crucial for VLBW infants.
Breast milk is essential but may not always suffice for VLBW infants.

Purpose of the Study:

To highlight the rapid development of nutritional deficiencies in VLBW infants.
To emphasize the risk of zinc deficiency and dehydration in breast-fed infants.
To underscore the importance of nutritional monitoring in all infant feeding scenarios.

Main Methods:

Review of nutritional requirements in VLBW infants.
Analysis of case reports on zinc deficiency and dehydration in breast-fed infants.
Clinical observation of nutritional status in neonatal populations.

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Main Results:

VLBW infants rapidly develop deficiencies in fat, minerals, trace elements, and vitamins.
Symptomatic zinc deficiency and hypernatremic dehydration can occur unexpectedly in breast-fed infants.
Nutritional adequacy requires careful monitoring, irrespective of feeding method.

Conclusions:

VLBW infants are highly susceptible to nutritional deficits.
Zinc deficiency and dehydration are potential risks even in exclusively breast-fed infants.
Continuous nutritional assessment is critical for optimal infant growth and development.