Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracorporeal photochemotherapy in progressive systemic sclerosis

F X Di Spaltro1, C Cottrill, C Cahill

  • 1Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.

International Journal of Dermatology
|June 1, 1993
PubMed
Summary

Extracorporeal photochemotherapy (ECP) improved symptoms and skin manifestations in patients with progressive systemic sclerosis (PSS). This immune-modulating therapy showed significant benefits with no serious side effects in early PSS cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

ISIS Penning source extraction studies reveal the 3-dimensional Child-Langmuir effect.

The Review of scientific instruments·2020
Same author

A comparison of the neuropsychological and neurological correlates of childhood, adolescent and adult bipolar disorders.

Acta neuropsychiatrica·2016
Same author

'Venus trapped, Mars transits': Cu and Fe redox chemistry, cellular topography and in situ ligand binding in terrestrial isopod hepatopancreas.

Open biology·2016
Same author

Augmenting cognitive behaviour therapy for post-traumatic stress disorder with emotion tolerance training: a randomized controlled trial.

Psychological medicine·2013

Area of Science:

  • Immunology
  • Dermatology
  • Rheumatology

Background:

  • Extracorporeal photochemotherapy (ECP) is an immune-modulating therapy with demonstrated efficacy in autoimmune diseases.
  • Progressive systemic sclerosis (PSS) is a debilitating autoimmune condition requiring effective treatment strategies.

Purpose of the Study:

  • To evaluate the therapeutic effects of ECP in patients diagnosed with active progressive systemic sclerosis.

Main Methods:

  • Nine patients with active PSS underwent ECP treatment over 2 consecutive days each month.
  • Therapy duration varied between 6 and 21 months for the participating patients.

Main Results:

  • Significant improvements were observed in skin condition, musculoskeletal function, and overall functional index.

Related Experiment Videos

  • Patient-reported symptoms such as Raynaud's phenomenon, dyspnea, fatigue, dysphagia, and arthralgias showed marked improvement.
  • Cutaneous ulcers healed, and pulmonary function stabilized in most patients without serious adverse events.

    • Conclusions:

    • Photopheresis (ECP) demonstrates potential as a beneficial treatment for selected early-stage progressive systemic sclerosis patients.
    • ECP offers a promising therapeutic option for managing PSS symptoms and disease progression.