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Cellular inflammatory responses to direct restorative composite resins
C Hansasuta1, M E Neiders, A Aguirre
1Department of Periodontology, State University of New York, School of Dental Medicine, Buffalo.
The Journal of Prosthetic Dentistry
|June 1, 1993
Summary
Dental composite resin particles trapped in oral tissues can cause persistent inflammation. Studies show these particles induce a granulomatous inflammatory response in rats that lasts for weeks.
Area of Science:
- Biomaterials Science
- Oral Pathology
- Immunology
Background:
- Dental composite resins are widely used in restorative dentistry.
- Particles of composite resin can become embedded in soft tissues during dental procedures.
- The inflammatory response to these embedded particles is not well understood.
Purpose of the Study:
- To investigate the soft tissue inflammatory response to embedded dental composite resin particles.
- To assess the long-term effects of composite resin particles in oral tissues.
Main Methods:
- Subcutaneous implantation of three commercial dental composite resin suspensions in rats.
- Histological examination of tissue reactions at 8 weeks post-implantation.
Main Results:
- Implantation of composite resin particles induced a persistent granulomatous inflammatory reaction.
- The inflammatory lesions showed significant infiltration of lymphocytes, fibroblasts, and epithelioid cells.
- The observed inflammatory response persisted for at least 8 weeks.
Conclusions:
- Embedded dental composite resin particles have the potential to elicit a chronic inflammatory response.
- This persistent inflammation may have implications for oral tissue health following dental restorative procedures.