[Developmental biotechnology and hypertension--emphasis on renin-angiotensin system]

The recent remarkable progress in molecular biology and developmental biotechnology has contributed to the evaluation of mechanism of hypertension. The renin-angiotensin system (RAS) is defined as an endocrine substance acting on blood pressure regulation. Accumulating evidence suggests the existence of tissue RAS in various organs, such as the brain, heart, vascular walls, adrenal gland, testis and ovary, in addition to the circulating RAS. However, it remains unclear how the RAS affects those tissues and high blood pressure. The advent of new developmental biotechnology gives an additional dimension to hypertension research. Such approach includes the generation of transgenic animals carrying the component of RAS genes and it should contribute to the elucidation of the RAS action in tissue function. In this manuscript, transgenic animals, produced to date, with emphasis on hypertension is introduced.