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[Molecular biology of endothelium-platelet interactions and thrombogenesis]
1Department of Cardiology, Jichi Medical School.
The net effect on vascular reactivity and thrombosis resulting from interactions of the endothelium with platelets is diverse. Platelet-endothelium interactions include platelet attachments to the vessels and the release of endothelium-derived platelet inhibitors. Identification of the platelet thrombin receptor revealed a unique proteolytic mechanism of receptor activation. The myriad of receptors, ligands, and the associated generation of intracellular messengers by heterotypic interactions offers numerous attractive targets for therapeutic intervention.
The net effect on vascular reactivity and thrombosis resulting from interactions of the endothelium with platelets is diverse. Platelet-endothelium interactions include platelet attachments to the vessels and the release of endothelium-derived platelet inhibitors. Identification of the platelet thrombin receptor revealed a unique proteolytic mechanism of receptor activation. The myriad of receptors, ligands, and the associated generation of intracellular messengers by heterotypic interactions offers numerous attractive targets for therapeutic intervention.