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[Pulsed steroid therapy for active ulcerative colitis patients]

N Oshitani1, A Kitano, H Okabe

  • 1Third Department of Internal Medicine, Osaka City University Medical School.

Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of Gastro-Enterology
|May 1, 1993
PubMed
Summary

Pulsed steroid therapy effectively treated ulcerative colitis patients, with most achieving clinical remission and improvement. This treatment showed a good safety profile, with minimal side effects observed in the study.

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Prediction of short-term outcome for patients with active ulcerative colitis.

Digestive diseases and sciences·2000

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pharmacology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • Severe and moderately severe UC cases often require intensive treatment strategies.
  • Pulsed steroid therapy is a potential therapeutic option for managing UC flares.

Purpose of the Study:

  • To evaluate the efficacy and safety of pulsed steroid therapy in patients with severe and moderately severe ulcerative colitis.
  • To assess clinical and endoscopic outcomes following pulsed corticosteroid administration.

Main Methods:

  • A total of 13 patients (6 severe, 7 moderate) with ulcerative colitis received pulsed steroid therapy.
  • The therapy involved intravenous administration of hydrocortisone or methylprednisolone (0.5-1g daily) for 3 consecutive days, followed by 4 days off, over 3-6 courses.

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  • Clinical remission, improvement, and endoscopic assessments were used to evaluate treatment response.

    • Main Results:

    • Ten out of 13 patients achieved clinical remission, with one showing improvement, and two experiencing treatment failure.
    • Endoscopic evaluation indicated remission in 5 patients, improvement in 6, and no improvement in 2.
    • Adverse events were generally mild; one patient experienced transient hyperglycemia, and three showed moon face. Steroid withdrawal syndrome was not observed.

    Conclusions:

    • Pulsed steroid therapy demonstrates significant efficacy in inducing clinical and endoscopic remission in patients with severe and moderately severe ulcerative colitis.
    • The treatment regimen is well-tolerated, with a favorable safety profile and minimal severe side effects, suggesting its utility in UC management.