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Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels
T Yamagishi1, K Ishii, N Taira
1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Japanese Journal of Pharmacology
|April 1, 1993
Abstract:
We investigated the effects of class III antiarrhythmic agents, d-sotalol, E-4031 and MS-551, on the currents of two cloned K channels, Kv1.2 (IKv1.2) and Kv1.4(IKv1.4), by using the Xenopus oocyte expression system. Both IKv1.2 and IKv1.4 were sensitive to 4-aminopyridine and quinidine, but insensitive to tetraethylammonium, d-sotalol, E-4031 and MS-551. The results suggest that some types of structural proteins may be necessary for class III agents to inhibit the cardiac cloned K channels.