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Olfactory system damage and brain catecholamines in the rat

D A Edwards, A J Schlosberg, S E McMaster

    Brain Research
    |January 31, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Olfactory bulb removal does not directly cause norepinephrine depletion. Instead, damage to nearby brain tissue during surgery is responsible for the observed drop in norepinephrine levels.

    Area of Science:

    • Neuroscience
    • Neurochemistry

    Background:

    • Previous studies link olfactory bulb removal to decreased telencephalic norepinephrine (NE).
    • The precise cause of this NE depletion has remained unclear.

    Purpose of the Study:

    • To investigate the relationship between olfactory system damage location/extent and telencephalic catecholamine depletion.
    • To clarify the mechanism behind norepinephrine reduction following olfactory system surgery.

    Main Methods:

    • Olfactory system surgery was performed.
    • Telencephalic catecholamine content was measured.
    • The extent and location of tissue damage were assessed.

    Main Results:

    • Norepinephrine depletion was not solely caused by olfactory bulb removal.

    Related Experiment Videos

  • Damage to tissue caudal to the olfactory bulbs correlated with norepinephrine loss.
  • Noradrenergic fibers ascending through this caudal tissue appear to be affected.

    • Conclusions:

    • The depletion of telencephalic norepinephrine after olfactory bulb ablation is an indirect consequence of surgical damage.
    • Damage to ascending noradrenergic pathways caudal to the olfactory bulbs is the primary cause of norepinephrine depletion.