Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Tumor lysis syndrome

K Arrambide¹, R D Toto

¹Department of Internal Medicine, University of Texas Southwestern, Dallas 75229-8856.

Seminars in Nephrology

|May 1, 1993

Summary

Tumor lysis syndrome (TLS) is a severe complication of cancer treatment. Prompt recognition and management, including hydration and allopurinol, can prevent kidney failure and improve patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of different ACE inhibitor combinations on albuminuria: results of the GUARD study.

Kidney international·2008

Same author

The effect of losartan on hemoglobin concentration and renal outcome in diabetic nephropathy of type 2 diabetes.

Kidney international·2007

Same author

Non-traditional risk factors predict coronary calcification in chronic kidney disease in a population-based cohort.

Kidney international·2007

Same author

Rationale and design of a study comparing two fixed-dose combination regimens to reduce albuminuria in patients with type II diabetes and hypertension.

Journal of human hypertension·2004

Same author

Hypertension and kidney literature review 2000.

Clinical nephrology·2002

Same author

Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.

JAMA·2001

Area of Science:

Oncology
Nephrology
Critical Care Medicine

Background:

Tumor lysis syndrome (TLS) is a medical emergency characterized by rapid tumor cell lysis.
It leads to metabolic derangements like hyperuricemia, hyperphosphatemia, hyperkalemia, and hypocalcemia.
Acute kidney injury is a common and severe complication, particularly in patients with rapidly growing cancers such as Burkitt's lymphoma.

Observation:

Massive tumor cell death triggers the release of intracellular contents into circulation.
This leads to electrolyte imbalances and potential renal dysfunction.
Patients with large tumor burdens are at highest risk.

Findings:

TLS is potentially preventable with early intervention.
Allopurinol therapy combined with aggressive intravenous fluid hydration can establish alkaline diuresis, mitigating uric acid nephropathy.
While renal failure is often reversible, life-threatening hyperkalemia and volume overload necessitate aggressive management, including hemodialysis.

Implications:

Early recognition and multidisciplinary team management in an intensive care setting are crucial.
Prompt intervention can forestall severe renal failure and improve short-term prognosis.
Controlling tumor burden with cytoreductive therapy alongside supportive care is essential for patient survival.

Related Experiment Videos