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[Fluoride release in children's toothpastes]

M Sättler1, D Hanfland, W E Wetzel

  • 1Abteilung Kinderzahnheilkunde, Zentrum für Zahn-, Mund- und Kieferheilkunde, Universität Giessen.

Schweizer Monatsschrift Fur Zahnmedizin = Revue Mensuelle Suisse D'Odonto-Stomatologie = Rivista Mensile Svizzera Di Odontologia E Stomatologia
|January 1, 1993
PubMed
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Sodium fluoride toothpaste released the most bioavailable fluoride for children, with over 70% dissolved. Amine fluoride toothpastes had over 45% free fluoride, while sodium monofluorophosphate toothpastes had 10% or less.

Area of Science:

  • Dental research
  • Fluoride chemistry
  • Pediatric oral health

Background:

  • Childhood dental caries remains a significant public health concern.
  • Fluoride toothpaste is a primary agent for caries prevention.
  • Understanding fluoride bioavailability from different formulations is crucial for efficacy.

Purpose of the Study:

  • To compare the in vitro and in vivo bioavailability of fluoride from six children's toothpastes available in Germany.
  • To assess the fluoride release characteristics of sodium monofluorophosphate, sodium fluoride, and amine fluoride formulations.

Main Methods:

  • Comparative in vitro analysis of fluoride concentration in toothpaste-saliva mixtures.
  • In vivo assessment of fluoride release in simulated oral conditions.

Related Experiment Videos

  • Quantification of dissolved fluoride proportions from different toothpaste types.

    • Main Results:

    • The sodium fluoride toothpaste exhibited the highest proportion of dissolved fluoride (>70%) in both test-tube and simulated oral cavity mixtures.
    • The amine fluoride toothpaste demonstrated significant free fluoride release (>45%).
    • Toothpastes containing sodium monofluorophosphate showed limited free fluoride release (≤10%).

    Conclusions:

    • Sodium fluoride appears to offer superior fluoride bioavailability compared to amine fluoride and sodium monofluorophosphate in children's toothpastes.
    • Formulation significantly impacts fluoride release and potential therapeutic efficacy.
    • Further clinical studies are warranted to confirm the in vivo effectiveness of high-bioavailability fluoride formulations.