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Renal cell carcinoma with osteoclast-like giant cells
A K el-Naggar1, K Gaber, N G Ordonez
1Department of Pathology, M.D. Anderson Cancer Center, Houston, Texas.
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1993
Abstract:
Primary extraskeletal epithelial neoplasms with osteoclast-like giant cells are rare. We describe a case of renal cell carcinoma with a sarcomatoid component and non-neoplastic osteoclast-like giant cells. The giant cells were noted in both the conventional and the sarcomatoid components of the neoplasm. Immunohistochemical studies indicate that these cells are monocyte/histiocyte in origin and most probably a host stromal reaction to the neoplasm.