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Related Experiment Videos

Age-dependent effect on the level of factor IX

J D Sweeney1, L A Hoernig

  • 1Hemophilia Center of Western New York, Erie County Medical Center, Buffalo 14215.

American Journal of Clinical Pathology
|June 1, 1993
PubMed
Summary

Factor IX coagulant (IX:C) and antigenic (IX:Ag) levels vary with age in healthy individuals. Caution is advised when interpreting low normal IX:C in children, as age impacts factor IX levels and ratios.

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Area of Science:

  • Hematology
  • Biochemistry
  • Pediatric Medicine

Background:

  • Factor IX is crucial for blood coagulation.
  • Understanding age-related changes in Factor IX is important for clinical interpretation.
  • Previous studies have not comprehensively analyzed Factor IX levels across a wide age range.

Purpose of the Study:

  • To investigate age-related changes in Factor IX coagulant activity (IX:C) and antigenic levels (IX:Ag) in healthy individuals.
  • To determine how the ratio of IX:Ag to IX:C changes with age.
  • To provide guidance for interpreting Factor IX levels in different age groups.

Main Methods:

  • Measurement of Factor IX:C and Factor IX:Ag in 120 healthy subjects.
  • Subjects ranged in age from 1 to 67 years.
  • Statistical analysis to identify age-dependent trends and ratios.

Main Results:

  • Factor IX:C levels were lowest in prepubertal subjects, plateaued in early adulthood, and increased in later adulthood (>45 years).
  • Factor IX:Ag showed a similar trend but increased disproportionately in early adulthood.
  • The ratio of IX:Ag to IX:C peaked in early adulthood due to differential increases.

Conclusions:

  • Age significantly influences both Factor IX coagulant and antigenic levels.
  • Low normal Factor IX:C levels in prepubertal children require careful interpretation.
  • Age must be considered when evaluating the ratio of antigenic to coagulant Factor IX activity.

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