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Related Experiment Videos

Microvascular volume contribution to hemorrhage compensation

R J Price1, J S Lee, T C Skalak

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville 22908.

The American Journal of Physiology
|June 1, 1993
PubMed
Summary

During hemorrhage, blood vessels in rat muscles rapidly constrict, shifting blood volume from microcirculation to macrocirculation. This microvascular response helps maintain systemic blood pressure by reducing hematocrit.

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Area of Science:

  • Physiology
  • Cardiovascular System
  • Microcirculation Research

Background:

  • Systemic blood pressure regulation involves microcirculation adjustments.
  • Blood volume shifts between microcirculation and macrocirculation aid in maintaining blood pressure during hemorrhage.
  • Hematocrit decreases during hemorrhage due to blood volume redistribution.

Purpose of the Study:

  • To determine the role of the microvasculature in hemorrhage compensation.
  • To measure microvascular diameter changes in response to hemorrhage.
  • To quantify blood volume shifts from microcirculation to macrocirculation.

Main Methods:

  • Anesthetized rats underwent a 13% blood volume hemorrhage.
  • Diameters of arterioles and venules in spinotrapezius muscles were measured.

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  • Anatomic modeling was used to estimate hematocrit decrease and blood volume shifts.

    • Main Results:

    • Microvascular diameters (arterioles and venules) decreased heterogeneously post-hemorrhage.
    • Smaller arterioles (<25 microns) showed greater diameter variation (61-100% of control).
    • Estimated systemic hematocrit decrease was 0.73%, with 3.74% blood volume shift.

    Conclusions:

    • Microvascular diameter changes provide a basis for rapid blood volume shifts during hemorrhage.
    • The microvasculature plays a crucial role in compensating for moderate blood loss.
    • Findings support the mechanism of blood volume redistribution for blood pressure regulation.