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Related Experiment Videos

Growth in atopic eczema

A A Massarano1, S Hollis, J Devlin

  • 1Department of Child Health, University of Manchester.

Archives of Disease in Childhood
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

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Children with atopic eczema affecting less than 50% of skin area show normal growth. However, those with more extensive eczema are significantly shorter, indicating impaired growth is linked to disease severity.

Area of Science:

  • Pediatric Endocrinology
  • Dermatology
  • Clinical Pediatrics

Background:

  • Atopic eczema is a common chronic inflammatory skin condition in children.
  • Growth impairment is a potential concern in children with severe atopic eczema.
  • Understanding factors influencing growth in this population is crucial for clinical management.

Purpose of the Study:

  • To investigate the relationship between the extent of atopic eczema and growth parameters in children.
  • To identify factors contributing to growth variations in children with atopic eczema.

Main Methods:

  • Study included 68 children aged 2-12 years diagnosed with atopic eczema.
  • Height Standard Deviation (SD) scores were calculated and correlated with the percentage of skin surface area affected.

Related Experiment Videos

  • Regression analysis was performed to assess the influence of parental height, disease extent, and treatments on growth.

    • Main Results:

    • Height SD scores showed a significant negative correlation with the surface area affected by eczema.
    • Children with less than 50% skin involvement (Group I) had normal mean height SD scores (-0.11).
    • Children with more than 50% skin involvement (Group II) were significantly shorter (mean SD score -0.83) than expected, even accounting for parental target height.

    Conclusions:

    • Impaired growth in children with atopic eczema is primarily associated with extensive skin surface area involvement (over 50%).
    • Parental height is the most significant determinant of a child's height.
    • Disease extent has a notable impact on growth, while dietary and topical steroid treatments have minimal effects.