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Ranitidine pharmacokinetics in newborn infants

M Fontana1, E Massironi, A Rossi

  • 1Fourth Department of Paediatrics, University of Milan Medical School, Italy.

Archives of Disease in Childhood
|May 1, 1993
PubMed
Summary

This study details ranitidine pharmacokinetics in newborns, finding an elimination half-life of approximately 207 minutes. These findings aid in developing safe ranitidine dosing regimens for infants.

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Area of Science:

  • Neonatal Pharmacology
  • Clinical Pharmacy
  • Pediatric Pharmacokinetics

Background:

  • Limited pharmacokinetic data exists for ranitidine in early neonatal life.
  • Intravenous ranitidine is used in newborns presenting with gastrointestinal bleeding symptoms.

Purpose of the Study:

  • To characterize the pharmacokinetics of intravenous ranitidine in newborn infants.
  • To provide data for optimizing ranitidine dosing strategies in neonates.

Main Methods:

  • Pharmacokinetic analysis of ranitidine in 27 newborn infants receiving a 2.4 mg/kg IV bolus.
  • Blood samples collected at various time points (30-360 minutes) post-administration.
  • Data fitted to a single exponential equation to determine key pharmacokinetic parameters.

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Main Results:

  • Mean elimination half-life: 207.1 (19.1) minutes.
  • Mean total volume of distribution: 1.52 (0.91) L/kg.
  • Mean total plasma clearance: 5.02 (0.46) mL/kg/min.

Conclusions:

  • Established pharmacokinetic parameters for ranitidine in newborns.
  • Data supports the development of evidence-based ranitidine treatment regimens for this population.
  • Further studies may explore dose-dependency of these parameters.