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Invasive sinusitis with intracranial extension caused by Curvularia lunata
Y Ismail1, R H Johnson, M V Wells
1Department of Medicine, Kern Medical Center, UCLA School of Medicine, Bakersfield.
Abstract:
Curvularia lunata has previously been linked to localized sinus infection in immunocompetent hosts. We treated a case of pansinusitis with extensive bone destruction and intracranial extension caused by C lunata. Curvularia lunata was identified when typical fungal macroconidia appeared on culture. Numerous surgical procedures, in addition to a 12-month course of antifungal therapy consisting of 4 g of intravenous amphotericin B and an 8-month course of 400 mg of oral ketoconazole daily, were required to control the infection. This unusual case of invasive sinusitis caused by C lunata alerts the treating physician to the presence of this mold and gives an overview of diagnostic method as well as the management.
Insights
This case report details a severe pansinusitis caused by Curvularia lunata, a fungus typically causing localized infections. Extensive treatment involving surgery and antifungals was necessary for this invasive fungal sinusitis.
Area of Science:
- Mycology
- Infectious Diseases
- Otolaryngology
Background:
- Curvularia lunata is commonly associated with localized sinus infections in immunocompetent individuals.
- Invasive fungal sinusitis can lead to severe complications, including bone destruction and intracranial extension.
- This study highlights a rare, aggressive presentation of Curvularia lunata infection.
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