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Related Experiment Videos

Epithelium-mesenchyme interconversion as example of epithelial plasticity

B Boyer1, J P Thiery

  • 1Laboratoire de Physiopathologie du Développement, Ecole Normale Supérieure, Paris, France.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|April 1, 1993
PubMed
Summary

Epithelium-mesenchymal transitions (EMT) involve cell changes crucial for development and disease. EMT-inducing molecules likely target cell adhesion systems, impacting cell dissociation and motility.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Pathology

Background:

  • Epithelium-mesenchymal transitions (EMT) are fundamental cellular processes.
  • EMT involves a shift from an epithelial to a mesenchymal cell phenotype.
  • These transitions are vital in embryogenesis and implicated in adult pathologies like cancer metastasis and wound repair.

Purpose of the Study:

  • To review the mechanisms and implications of epithelium-mesenchymal transitions (EMT).
  • To highlight the role of cell adhesion and extracellular matrix interactions in EMT.
  • To identify potential cellular targets of EMT-inducing molecules.

Main Methods:

  • Literature review of studies on embryonic and in vitro EMT.
  • Analysis of research on cell-matrix and intercellular adhesion.

Related Experiment Videos

  • Examination of the role of growth factors and extracellular matrix components.

    • Main Results:

    • Embryonic EMT highlights the importance of cell adhesion and matrix interactions for cell dissociation and motility.
    • In vitro studies reveal growth factors and extracellular matrix components initiate EMT.
    • Cellular targets of EMT-inducing molecules are likely involved in cell adhesion systems.

    Conclusions:

    • EMT is a critical process regulated by cell adhesion and extracellular matrix interactions.
    • Understanding EMT targets is key to addressing associated pathologies.
    • EMT-inducing molecules likely modulate cell adhesion systems.