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Increased serum carnitine concentration in renal insufficiency
Clinical Chemistry
|February 1, 1977
Summary
Serum carnitine levels were often elevated in patients with kidney disease. This increase in carnitine may be as significant as other waste product elevations in renal insufficiency.
Area of Science:
- Biochemistry
- Nephrology
- Clinical Chemistry
Background:
- Carnitine plays a vital role in cellular energy metabolism.
- Elevated serum levels of certain metabolites are indicative of impaired kidney function.
Purpose of the Study:
- To investigate serum carnitine concentrations in patients with various diseases.
- To determine the prevalence of elevated serum carnitine in patients with renal insufficiency.
Main Methods:
- Serum samples were collected from patient groups with different diseases.
- Carnitine concentrations were measured using biochemical assays.
Main Results:
- Serum carnitine levels were frequently found to be above the normal range in patients diagnosed with renal insufficiency.
- No specific mention of carnitine levels in other disease groups.
Conclusions:
- Elevated serum carnitine is a common finding in patients with renal insufficiency.
- The clinical significance of increased serum carnitine in renal insufficiency may parallel that of other commonly monitored renal biomarkers like urea nitrogen, creatinine, and uric acid.