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Lactobacilli and the normal human anaerobic microflora

A Lidbeck1, C E Nord

  • 1Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Sweden.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 1, 1993
PubMed
Summary

Antimicrobial drugs can disrupt the gut microbiome, reducing beneficial lactobacilli. Maintaining lactobacilli levels is crucial for gut health and preventing infections.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Human Microbiome Research

Background:

  • The human microflora, particularly the intestinal microflora, is a complex ecosystem vital for host metabolic functions and defense against infections.
  • Antimicrobial agents can disrupt this delicate balance, decreasing colonization resistance and altering bacterial metabolic activities.
  • Gastrointestinal disturbances and a reduction in lactobacilli are common side effects of antimicrobial therapy.

Purpose of the Study:

  • To highlight the importance of the intestinal microflora and the role of lactobacilli.
  • To underscore the negative impact of antimicrobial agents on the gut microbiome.
  • To emphasize the necessity of maintaining or increasing lactobacilli levels for host health.

Main Methods:

  • Review of existing literature on human microflora, antimicrobial effects, and lactobacilli functions.
  • Analysis of the mechanisms by which lactobacilli contribute to colonization resistance.
  • Examination of studies demonstrating the protective effects of lactobacilli against gastrointestinal pathogens.

Main Results:

  • Antimicrobial therapy can lead to a significant decrease in lactobacilli populations within the intestinal microflora.
  • Lactobacilli produce lactic acid, acetic acid, hydrogen peroxide, and antimicrobial substances that support colonization resistance.
  • Studies suggest lactobacilli possess protective properties against potential gastrointestinal pathogens.

Conclusions:

  • Maintaining or increasing lactobacilli levels in the intestinal microflora is important due to their beneficial properties.
  • Lactobacilli play a key role in supporting gut health and preventing infections, especially during or after antimicrobial treatment.
  • Further research and strategies to preserve lactobacilli are warranted to mitigate the adverse effects of antimicrobial use.

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