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Related Experiment Videos

Antimicrobial resistance in Bacteroides

B A Rasmussen1, K Bush, F P Tally

  • 1Infectious Disease Section, Lederle Laboratories, American Cyanamid Company, Pearl River, New York 10965.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 1, 1993
PubMed
Summary
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Antimicrobial resistance in Bacteroides species impacts anaerobic infection treatment. Understanding resistance mechanisms, like beta-lactamase production and ribosomal modification, is crucial for effective chemotherapy selection.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance in Bacteroides species poses challenges for treating anaerobic infections.
  • Variations in susceptibility patterns are linked to hospital, geographic, and prescribing practices.
  • Resistance to key antibiotics like beta-lactams, tetracycline, clindamycin, and metronidazole is documented.

Purpose of the Study:

  • To review the mechanisms of antimicrobial resistance in Bacteroides species.
  • To highlight the impact of resistance on chemotherapy selection for anaerobic infections.
  • To emphasize the need for understanding resistance to guide new drug development and treatment.

Main Methods:

  • Literature review of studies on Bacteroides resistance mechanisms.

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  • Analysis of documented resistance patterns and their association with antibiotics.
  • Examination of molecular mechanisms underlying resistance to various drug classes.

    • Main Results:

    • Beta-lactam resistance primarily involves beta-lactamase production (penicillinases, cephalosporinases, metallo-beta-lactamases).
    • Tetracycline resistance is linked to the tetQ class via ribosomal protection.
    • Clindamycin resistance results from ribosomal modification, and metronidazole resistance involves complex changes in antibiotic uptake and enzyme activity.

    Conclusions:

    • Emergence of multidrug resistance in Bacteroides is a significant concern.
    • Understanding resistance mechanisms is vital for informed therapeutic choices.
    • Knowledge gained can facilitate the development of novel antimicrobial agents.