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Isoniazid induced encephalopathy in dialysis patients
1Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|April 1, 1993
Abstract:
Three dialysis patients with extrapulmonary tuberculosis developed confusion 4-14 days after commencement of treatment with anti-tuberculosis drugs, despite the use of prophylactic pyridoxine. Full recovery of conscious state resulted within 1 week in all patients after stopping isoniazid. In 2 patients confusion recurred on rechallenge of the drug. The risk factors of isoniazid induced encephalopathy and the dosage of isoniazid in uraemic patients were discussed.