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Related Experiment Videos

A spun elastomeric graft for dialysis access

W J Drasler1, G J Wilson, M D Stenoien

  • 1Possis Medical, Inc., Minneapolis, MN 55441.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|April 1, 1993
PubMed
Summary

This study introduces a novel elastomeric vascular graft created with electrostatic spinning, demonstrating high patency rates and excellent handling for dialysis access. The composite graft shows promise for both hemodialysis and peripheral vascular reconstruction.

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Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Vascular grafts are crucial for hemodialysis access and peripheral vascular reconstruction.
  • Existing grafts face challenges with patency, infection, and mechanical properties.

Purpose of the Study:

  • To develop and evaluate a new composite elastomeric vascular graft using electrostatic spinning technology.
  • To assess the graft's performance in a canine arteriovenous shunt model, focusing on patency, handling, and tissue integration.

Main Methods:

  • A composite graft was fabricated using microfibrous polydimethylsiloxane, polyester yarn, and a helical bead via electrostatic spinning.
  • Eighteen grafts were implanted in a canine femoral arteriovenous shunt model for 12 months.
  • Grafts were cannulated weekly, evaluated for handling and puncture characteristics, and assessed via angiography and histology.

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Main Results:

  • The grafts exhibited excellent handling and puncture characteristics with no wall bleeding.
  • Cumulative patency was 88% at 6 months and 80% at 1 year.
  • Histology revealed fibroconnective encapsulation, tissue ingrowth, and a microvascular network with minimal thrombus and no pulmonary emboli.

Conclusions:

  • The novel elastomeric vascular graft demonstrates significant promise for dialysis access due to its mechanical properties and biological integration.
  • The graft's design and fabrication method show potential for future applications in small-diameter peripheral vascular reconstruction.