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Lethal posttransfusion graft-versus-host disease. Report of four cases
1Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
Abstract:
Four cases of posttransfusion graft-versus-host disease are reported. Three were caused by high-dose transfusion of non-irradiated fresh blood during open-heart surgery and 1 by the contaminated lymphocytes in packed red blood cells transfused for renal injury. In 1 patient, change of HLA type of peripheral lymphocytes was demonstrated.