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Related Experiment Videos

Regulation of gene expression and cell function by extracellular matrix

P L Jones1, C Schmidhauser, M J Bissell

  • 1Life Sciences Division, Lawrence Berkeley Laboratory, University of California 94720.

Critical Reviews in Eukaryotic Gene Expression
|January 1, 1993
PubMed
Summary

The extracellular matrix (ECM) is a network of proteins crucial for cell signaling and tissue function. This review highlights the ECM's fundamental role in regulating gene expression and maintaining tissue-specific characteristics.

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Multicellular organisms feature cells surrounded by an extracellular matrix (ECM).
  • The ECM is a complex network of glycoproteins and proteoglycans.
  • It functions as an informational entity, integrating structural and functional signals.

Purpose of the Study:

  • To demonstrate the ECM's fundamental role in controlling gene expression.
  • To elucidate the ECM's role in inducing and maintaining tissue-specific functions.
  • To revisit a model of ECM, cytoskeleton, and nuclear matrix interaction in gene regulation.

Main Methods:

  • Literature review of existing research on the extracellular matrix.
  • Analysis of models describing ECM-mediated gene expression.

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  • Synthesis of information on ECM's role in tissue function.

    • Main Results:

    • The ECM is integral to cellular communication and tissue organization.
    • ECM components actively participate in signal transduction pathways.
    • The ECM influences gene expression patterns critical for tissue identity.

    Conclusions:

    • The extracellular matrix is a key regulator of gene expression.
    • The ECM is essential for the induction and maintenance of tissue-specific functions.
    • A coordinated interaction between ECM, cytoskeleton, and nuclear matrix governs tissue-specific gene expression.