Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Echo-planar MR imaging of human brain oxygenation changes

M K Stehling1, F Schmitt, R Ladebeck

  • 1Department of Neurosurgery, University of Erlangen, Germany.

Journal of Magnetic Resonance Imaging : JMRI
|May 1, 1993
PubMed
Summary

Hypoxia causes brain signal changes detectable by echo-planar MRI. Researchers observed significant gray and white matter signal attenuation, suggesting deoxyhemoglobin as a contrast agent for brain oxygen use.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolomics of stallion seminal plasma: Identification of potential fertility biomarkers based on differences between high and low pregnancy stallions.

Journal of equine veterinary science·2026
Same author

[Assessment tool's validation study for a simulation-based skin suturing skill].

Annales de chirurgie plastique et esthetique·2024
Same author

Retrospective study to estimate the prevalence and describe the clinicopathological characteristics, treatments received, and outcomes of HER2-low breast cancer.

ESMO open·2023
Same author

The German Network for Personalized Medicine to enhance patient care and translational research.

Nature medicine·2023
Same author

A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.

Journal of intellectual disability research : JIDR·2020
Same author

ACCIDENTAL FINDING OF SYNCHRONOUS BILATERAL DUCTAL CARCINOMA IN SITU IN A YOUNG MAN REFERRED TO MASTECTOMY DUE TO GYNECOMASTIA - AND WHAT IF LIPOSUCTION HAVE BEEN USED? CASE REPORT.

Acta chirurgiae plasticae·2020

Area of Science:

  • Neuroimaging
  • Physiology
  • Medical Physics

Background:

  • Hypoxia, or low oxygen levels, affects brain function.
  • Magnetic Resonance (MR) imaging is sensitive to changes in blood oxygenation.

Purpose of the Study:

  • To observe human brain signal intensity changes during induced hypoxia.
  • To correlate these changes with deoxyhemoglobin levels.
  • To explore the potential of deoxyhemoglobin as an intravascular contrast agent.

Main Methods:

  • Utilized echo-planar MR imaging to monitor brain signal intensity.
  • Induced controlled hypoxia through prolonged apnea.
  • Measured arterial blood deoxyhemoglobin levels using a pulse oximeter.

Main Results:

Related Experiment Videos

  • Observed significant signal attenuation in both gray matter (13%) and white matter (20%) during increasing hypoxia (0%-42% deoxyhemoglobin).
  • Demonstrated a correlation between rising deoxyhemoglobin levels and MR signal loss.

Conclusions:

  • Deoxyhemoglobin acts as an intravascular susceptibility contrast agent in the brain.
  • This phenomenon can be leveraged to assess local cerebral oxygen utilization using MR imaging.