Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GnRH analogues for contraception

H M Fraser1

  • 1MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK.

British Medical Bulletin
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contrast imaging ultrasound detects abnormalities in the marmoset ovary.

American journal of primatology·2012
Same author

Ovarian VEGF(165)b expression regulates follicular development, corpus luteum function and fertility.

Reproduction (Cambridge, England)·2012
Same author

Molecular mechanisms of ovarian hyperstimulation syndrome: paracrine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability.

Human reproduction (Oxford, England)·2009
Same author

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.

American journal of physiology. Endocrinology and metabolism·2009
Same author

Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the human.

Human reproduction (Oxford, England)·2008
Same author

Regulation of endothelial proliferation by the renin-angiotensin system in human umbilical vein endothelial cells.

Reproduction (Cambridge, England)·2008
Same journal

Augmentation in Achilles tendon repair: evidence versus enthusiasm.

British medical bulletin·2026
Same journal

Regional musculoskeletal pain in workers-is the traditional medical model increasing disability?

British medical bulletin·2026
Same journal

Human health in relation to visible, functional, and accessible green space: a systematic review and narrative synthesis of the 3 + 30 + 300 guideline.

British medical bulletin·2026
Same journal

Muscle herniae in exercise-induced leg pain: diagnostic pitfalls and the 'repair paradox'.

British medical bulletin·2026
Same journal

Scaffolds and platelet concentrates in bone regenerative medicine: applications, mechanisms, and future approaches.

British medical bulletin·2026
Same journal

Back squat and deadlift fatiguing protocols elicit distinct countermovement jump profiles: phase-specific predictors and soreness responses.

British medical bulletin·2026
See all related articles

Gonadotropin-releasing hormone (GnRH) analogues offer contraceptive potential by suppressing the reproductive axis. GnRH antagonists show promise for both female and male contraception, with ongoing research into combination therapies.

Area of Science:

  • Reproductive endocrinology
  • Pharmacology
  • Contraceptive development

Background:

  • Gonadotropin-releasing hormone (GnRH) analogues can suppress the pituitary-gonadal axis.
  • GnRH agonists prevent ovulation through gonadotroph desensitization, forming a basis for contraception.
  • Long-term GnRH agonist use presents challenges like irregular bleeding and hypoestrogenism.

Purpose of the Study:

  • To explore the contraceptive potential of GnRH analogues, including agonists and antagonists.
  • To evaluate the advantages of GnRH antagonists, such as immediate action and cycle interruption.
  • To consider combination therapies for enhanced contraceptive efficacy and safety.

Main Methods:

  • Review of existing literature on GnRH analogue mechanisms and clinical applications.
Keywords:
BiologyBreast CancerCancerContraceptionContraceptive MethodsDiseasesEndocrine SystemFamily PlanningFollicle Stimulating HormoneGenitaliaGenitalia, FemaleGonadotropinsGonadotropins, PituitaryHormonesLuteinizing HormoneMale ContraceptionMenstrual CycleMenstruationNeoplasmsOral ContraceptivesOral Contraceptives, CombinedOvarian EffectsOvaryPhysiologyReproductionUrogenital System

Related Experiment Videos

  • Discussion of the pharmacological properties of GnRH agonists and antagonists.
  • Exploration of potential combination strategies with estrogen, progestin, and testosterone.

    • Main Results:

    • Continuous GnRH agonist administration leads to ovulation prevention but with variable estrogen effects.
    • GnRH antagonists offer immediate inhibition and can be used at any cycle stage.
    • Potential for male contraception using GnRH antagonists combined with testosterone.

    Conclusions:

    • GnRH analogues are established contraceptives, with agonists used for ovulation prevention.
    • GnRH antagonists present a promising alternative with immediate action and broader application.
    • Combination therapies with GnRH analogues may improve contraceptive benefits and health outcomes.