Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigestogens

D T Baird1

  • 1University of Edinburgh, Department of Obstetrics and Gynaecology, UK.

British Medical Bulletin
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time to streamline access to termination of pregnancy.

BJOG : an international journal of obstetrics and gynaecology·2014
Same author

Regulation of folliculogenesis and the determination of ovulation rate in ruminants.

Reproduction, fertility, and development·2011
Same author

Glucose uptake and lactate production by the autotransplanted ovary of the ewe during the luteal and follicular phases of the oestrous cycle.

Theriogenology·2010
Same author

Effect of direct ovarian infusion of bone morphogenetic protein 6 (BMP6) on ovarian function in sheep.

Biology of reproduction·2009
Same author

Advances in recombinant DNA technology: corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequency.

Human reproduction update·2009
Same author

The science, medicine, and future of contraception.

The Western journal of medicine·2008
Same journal

Human health in relation to visible, functional, and accessible green space: a systematic review and narrative synthesis of the 3 + 30 + 300 guideline.

British medical bulletin·2026
Same journal

Muscle herniae in exercise-induced leg pain: diagnostic pitfalls and the 'repair paradox'.

British medical bulletin·2026
Same journal

Scaffolds and platelet concentrates in bone regenerative medicine: applications, mechanisms, and future approaches.

British medical bulletin·2026
Same journal

Back squat and deadlift fatiguing protocols elicit distinct countermovement jump profiles: phase-specific predictors and soreness responses.

British medical bulletin·2026
Same journal

Enhancing bone healing through osteogenic medium components: biological roles, mechanisms, and clinical applications.

British medical bulletin·2026
Same journal

Moral injury in healthcare workers: causes & interventions.

British medical bulletin·2026
See all related articles

Antigestogens like mifepristone block progesterone's effects. They offer safe early pregnancy termination and potential new contraceptive and labor-induction methods.

Area of Science:

  • Reproductive endocrinology
  • Pharmacology

Background:

  • Antigestogens inhibit progesterone synthesis or action.
  • Mifepristone (RU 486) is a high-affinity progesterone receptor antagonist.
  • Progesterone is crucial for reproductive functions.

Purpose of the Study:

  • To review the applications of antigestogens, particularly mifepristone.
  • To explore their role in pregnancy termination, contraception, labor induction, and hormone-dependent conditions.

Main Methods:

  • Review of scientific literature on mifepristone and other antigestogens.
  • Analysis of clinical trial data for safety and efficacy.

Main Results:

  • Mifepristone with prostaglandins is a safe, effective alternative for early pregnancy termination.
Keywords:
Abortifacient AgentsAbortion, Drug InducedAbortion, InducedBiologyBreast CancerCancerCritiqueDiseasesEndocrine SystemFamily PlanningFertility Control, PostcoitalFertility Control, PostconceptionFollicle Stimulating HormoneGonadotropinsGonadotropins, PituitaryHormone AntagonistsHormonesLactationMaternal PhysiologyNeoplasmsPhysiologyProgestational HormonesProgesteroneRu-486--beneficial effects

Related Experiment Videos

  • Preliminary data suggest contraceptive and labor-inducing potential.
  • Mifepristone shows promise for treating endometriosis, fibroids, and certain cancers.

    • Conclusions:

    • Antigestogens represent a significant advancement in reproductive health.
    • They offer new avenues for managing pregnancy, contraception, and hormone-related diseases.
    • Hormone antagonists provide novel methods for reproductive function regulation.