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Penetration of mitomycin C in human bladder
M G Wientjes1, R A Badalament, R C Wang
1Division of Urology, Ohio State University, Columbus 43210-1228.
Cancer Research
|July 15, 1993
Summary
Intravesical mitomycin C (MMC) effectively penetrates bladder tissue, especially when administered shortly before radical cystectomy. Higher MMC concentrations are found in urothelium and tumors compared to deeper muscle layers.
Area of Science:
- Urology
- Pharmacology
- Oncology
Background:
- Intravesical chemotherapy is a standard treatment for bladder cancer.
- Understanding drug penetration is crucial for optimizing treatment efficacy.
Purpose of the Study:
- To investigate the penetration of mitomycin C (MMC) into bladder tissue following intravesical instillation.
- To correlate MMC concentration with tissue depth and tumor presence.
Main Methods:
- Patients undergoing radical cystectomy received intravesical MMC (20 mg/40 ml) for 60-120 minutes.
- Bladder tissue was analyzed for MMC concentration at various depths.
- Plasma concentrations and tumor tissue uptake were also assessed.
Main Results:
- Significant MMC concentrations were found in bladder wall tissues when drained shortly before vascular ligation.
- MMC concentration decreased with tissue depth, with a half-distance of approximately 500 microns.
- Tumor tissues generally showed higher MMC concentrations than adjacent normal tissues.
Conclusions:
- Intravesical MMC demonstrates measurable penetration into bladder tissue, particularly in the urothelium and lamina propria.
- Drug delivery timing and urine concentration significantly impact tissue uptake.
- Higher MMC concentrations in tumors suggest potential for improved therapeutic outcomes.