Related Experiment Videos
Stereochemistry and dynamics of the inclusion complex of (S)-(+)-fenoprofen with cyclomaltoheptaose
G Uccello-Barretta1, C Chiavacci, C Bertucci
1Centro di Studio del CNR per le Macromolecole Stereordinate ed Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Pisa, Italy.
Carbohydrate Research
|April 23, 1993
Abstract:
The inclusion complex of the calcium salt of (S)-2-(3-phenoxyphenyl)propionic acid with cyclomaltoheptaose (beta-cyclodextrin) was investigated by 1H NMR spectroscopy. The stoichiometry of the complex was determined by the continuous variation method and the association constant by the Benesi-Hildebrand procedure. Measurements of proton selective relaxation rates allowed the dynamics of the complex to be investigated and the determination of intermolecular 1H(1H)-NOE enhancements revealed the stereochemistry in solution.