Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Morphofunctional correlations in dilated cardiomyopathies]

R Razzolini1, G M Boffa, F De Conti

  • 1Servizio di Emodinamica, Università degli Studi, Padova.

Cardiologia (Rome, Italy)
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal evaluation of carpal tunnel syndrome in a pre-symptomatic TTR mutation carrier.

Journal of the neurological sciences·2023
Same author

The applications of Wearable Cardioverter Defibrillators in Heart Failure and beyond.

La Clinica terapeutica·2023
Same author

Funneling Spontaneous Emission into Waveguides via Epsilon-Near-Zero Metamaterials.

Nanomaterials (Basel, Switzerland)·2021
Same author

Multi-dorsal metacarpal artery perforator adipofascial turnover flap for index to little finger reconstruction: Anatomical study and clinical application.

Hand surgery & rehabilitation·2020
Same author

Actinomyces and MRONJ: A retrospective study and a literature review.

Journal of stomatology, oral and maxillofacial surgery·2020
Same author

COVID-19 strategy in organizing and planning orthopedic surgery in a major orthopedic referral center in an area of Italy severely affected by the pandemic: experience of the Department of Orthopedics, University of Padova.

Journal of orthopaedic surgery and research·2020
Same journal

[Prevention in coronary postangioplasty restenosis with omega-3 fatty acids. Results of the Italian study on prevention of restenosis with esapent (ESPRIT)].

Cardiologia (Rome, Italy)·2002
Same journal

[Results of GISSI Prevenzione: diet, drugs, and cardiovascular risk. Researchers of GISSI Prevenzione].

Cardiologia (Rome, Italy)·2002
Same journal

[New therapeutic strategies in heart failure. Which patients need defibrillation backup?].

Cardiologia (Rome, Italy)·2002
Same journal

[Electromechanical re-synchronization with sequential heart stimulation as a new non-pharmacologic treatment of advanced heart failure. Physiopathologic features and clinical results].

Cardiologia (Rome, Italy)·2002
Same journal

[New therapeutic strategies in heart failure. Pharmacologic therapy].

Cardiologia (Rome, Italy)·2002
Same journal

[Genetics as a guide for antihypertensive therapy: future perspectives].

Cardiologia (Rome, Italy)·2002
See all related articles

In dilated cardiomyopathy, fibrosis correlates with ejection fraction, but myocyte percentage does not. Myocyte loss over time may worsen heart failure by increasing fibrosis.

Area of Science:

  • Cardiology
  • Histopathology
  • Biomedical Engineering

Background:

  • Dilated cardiomyopathy (DCM) is characterized by impaired left ventricular function.
  • The relationship between cardiac histology and ventricular function in DCM requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between left ventricular function indices and histological findings (myocytes, fibrosis, interstitium) in patients with DCM.

Main Methods:

  • Studied 26 DCM patients undergoing cardiac catheterization and angiography.
  • Obtained interventricular septum biopsy specimens for automated histological analysis.
  • Correlated hemodynamic parameters with histological data using the least square method.

Main Results:

Related Experiment Videos

  • Significant correlation found between fibrosis percentage and left/right ventricular ejection fraction.
  • Significant correlation observed between myocyte percentage and right ventricular ejection fraction and disease duration.
  • Left ventricular function indices did not correlate with myocyte percentage.

Conclusions:

  • Fibrosis, not myocyte percentage, is linked to ventricular ejection fraction in DCM.
  • Decreased myocyte content over time may contribute to heart failure progression via fibrosis.
  • Biopsy site (right ventricle) might influence correlations with right ventricular function.