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Acetaminophen-induced eosinophilic pneumonia
1Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
Abstract:
We present the first case (to our knowledge) of acetaminophen-induced eosinophilic pneumonia. Although the patient had taken an acetaminophen-containing combination drug, Kinuya-chinnetsu, for only three days, the abnormal shadow on his chest radiograph continued for about a month. Lymphocyte stimulation tests showed that both Kinuya-chinnetsu and acetaminophen induced the proliferation of peripheral blood lymphocytes.
Insights
This study reports the first known case of eosinophilic pneumonia caused by acetaminophen. Acetaminophen and a combination drug triggered lymphocyte proliferation, despite short-term use.
Area of Science:
- Pulmonology
- Pharmacology
- Toxicology
Background:
- Drug-induced lung injury is a recognized clinical concern.
- Eosinophilic pneumonia can manifest with diverse etiologies.
- Acetaminophen is a common over-the-counter analgesic and antipyretic.
Observation:
- A patient developed an abnormal chest radiograph shadow after three days of taking Kinuya-chinnetsu, a combination drug containing acetaminophen.
- The radiographic abnormality persisted for approximately one month despite the short duration of drug exposure.
Findings:
- Lymphocyte stimulation tests confirmed that both Kinuya-chinnetsu and acetaminophen induced peripheral blood lymphocyte proliferation.
- This suggests a potential immune-mediated mechanism underlying the observed lung pathology.
Implications:
- This case highlights acetaminophen as a potential cause of eosinophilic pneumonia.
- It underscores the importance of considering drug-induced lung injury in patients with unexplained pulmonary infiltrates.
- Further investigation into the immunopharmacological effects of acetaminophen may be warranted.