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Fosfomycin in puerperal infections and its elimination in lochia
Abstract:
31 patients suffering from puerperal endometritis, 16 of whom with other concomitant infections (sepsis, infection of episiotomy, pyelonephritis) were treated with fosfomycin. 86% of the germs isolated were sensitive to fosfomycin. The results obtained have been excellent in 26 patients (84%) and null in 5 (16%). Fosfomycin showed to be an antibiotic of wide-spectrum, and it acted very rapidly, since apirexia of the patients was achieved after 2-3 days of treatment. The antibiotic had perfect tolerance. No disagreeable secondary effects nor changes in the haematological data were observed. We have also carried out a study on the elimination in lochia of fosfomycin in a group of 21 patients with normal birth and puerperium. The concentrations of the antibiotic in lochia, although variable, are sufficient to achieve the desired bactericide action.
Insights
Fosfomycin effectively treated puerperal endometritis in 86% of patients, showing rapid action and excellent tolerance. This wide-spectrum antibiotic achieved fever reduction within 2-3 days, with sufficient concentrations in lochia for bactericidal effect.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pharmacology
Background:
- Puerperal endometritis is a significant postpartum infection.
- Concomitant infections can complicate treatment outcomes.
- Evaluating novel antibiotic efficacy is crucial for maternal health.
Purpose of the Study:
- To assess the efficacy and safety of fosfomycin in treating puerperal endometritis.
- To determine the spectrum of activity and speed of action of fosfomycin.
- To investigate fosfomycin concentrations in lochia.
Main Methods:
- A clinical study involving 31 patients with puerperal endometritis.
- Inclusion of patients with concomitant infections (sepsis, episiotomy, pyelonephritis).
- Microbiological sensitivity testing for isolated germs against fosfomycin.
- Pharmacokinetic analysis of fosfomycin elimination in lochia for 21 patients.
Main Results:
- 86% of isolated microorganisms were sensitive to fosfomycin.
- Excellent treatment outcomes observed in 84% of patients (26/31).
- Rapid defervescence achieved within 2-3 days, indicating swift action.
- Fosfomycin demonstrated excellent tolerance with no adverse effects or hematological changes.
- Sufficient fosfomycin concentrations were detected in lochia for bactericidal action.
Conclusions:
- Fosfomycin is a highly effective and well-tolerated antibiotic for puerperal endometritis.
- Its broad-spectrum activity and rapid action make it a valuable therapeutic option.
- Adequate concentrations in lochia support its use in treating postpartum uterine infections.